
Washington D.C., Feb 23, 2017 / 02:50 am (CNA/EWTN News).- Recent American guidelines for human gene modification have raised important ethical questions, especially with regard to modifying the genes of unborn children and of reproductive cells.
The National Academy of Sciences last week released a 261-page report on guidelines for editing the human genome to treat diseases and other applications. The report covers a wide array of topics, from the editing of adult cells for therapies such as cancer treatment, to the editing of embryos and germ cells (reproductive cells, i.e. ova and sperm), to the question of human enhancement.
John DiCamillo, an ethicist at the National Catholic Bioethics Center, spoke to CNA about the perils and the promises of gene editing, as well as the oversights contained in the National Academy of Sciences’ report.
“Gene editing generally can be morally legitimate if it has a directly therapeutic purpose for a particular patient in question, and if we’re sure we’re going to limit whatever changes to this person,” DiCamillo explained. In this regard, the report’s guidelines for laboratory treatment of somatic – or non-reproductive – cells and human trials of somatic cell treatments were reasonable, he noted.
DiCamillo pointed to upcoming clinical gene therapy trials for cancer and proposed gene therapy treatments for disorders such as sickle cell disease. However, it’s important to limit these trials to non-embryonic persons, to ensure that the modifications – intended as well as unintended – are not carried in the patient’s reproductive cells.
While this would mean that patients treated for inheritable diseases “could still transmit it to their children,” any children who then developed the disease could themselves be treated through the same process.
The question of transmission to descendents opens up two more points discussed in the National Academy of Sciences report: the modification of ova and sperm, as well as edits to the genomes of embryos. Both of these changes would mean that people would maintain these edits in all of their cells for all of their lives – and could pass on these edited genes to new generations.
“There could be limited situations that could exist where the germ line could be legitimately edited. In other words, making changes to sperm, to eggs, or to early embryos as a way of potentially addressing diseases – inheritable diseases and so forth,” DiCamillo stated.
However, permitting edits to germ line cells could also be “very dangerous on multiple levels,” he warned.
There are considerable, and not yet fully controllable, risks to genetic manipulation. A person conceived with edited genes could experience a range of “unintended, perhaps harmful, side effects that can now be transmitted, inherited by other individuals down the line.” An embryo who experiences gene modification could also carry and pass on edited genes, particularly if edits were performed before his or her reproductive cells began to differentiate themselves.
The National Academy of Sciences’ regulations surrounding germ cells and embryos are also problematic for what they overlook, DiCamillo commented.
Manipulating sperm and ova requires removing them from a person’s body; if conception is achieved with these cells, it is nearly always through in vitro methods. This practice of in vitro fertilization is held by the Church to be ethically unacceptable because it dissociates procreation from the integrally personal context of the conjugal act.
In addition, scientific researchers rarely differentiate between experimentation on sperm or ova – which are cells that come from a human subject – and embryos, which are distinct persons with their own distinct genomes, DiCamillo noted.
The National Academy of Sciences’ guidelines reflect this lack of distinction between cells and embryos. “That’s very misleading because embryos are not germ line cells; they are new human beings,” DiCamillo said.
For research on embryos to be ethical, he continued, therapies should be ordered to treating and benefitting that “that particular embryo, not just for garnering scientific knowledge or seeing what’s going to happen.” DiCamillo condemned policies that see destruction of embryonic persons as a back-up if research does not go as planned, as well as current policies that require destruction of embryos as standard procedure.
“We’d be in that area of very dangerous exploitation of human life and destruction of human life,” he warned.
While the guidelines stumble across ethical roadblocks in regards to gamete and embryo research, the new report’s rules regarding human enhancement are strong, DiCamillo said.
The ability to edit genomes could also be used for purposes other than medical treatment. A whole host of human traits could be enhanced or changed, such as vision, intelligence, or abilities. “There’s any number of things that we could do to change the qualities of human beings themselves and make them, in a sense, super-humans … this is something that would also be an ethical problem on the horizon,” he warned.
The existence of these gene altering therapies raises a question of how much modification and enhancement is permissible. DiCamillo praised the report for its recommendation “entirely against enhancement efforts and that these should not be allowed.”
Currently, gene editing of both germ cells and somatic cells is legal in the United States, including on embryos. However, various US government institutions have policies in place prohibiting federal funding of such research efforts on germ cells and on embryos.
Furthermore, Food and Drug Administration regulations prohibit gene modification on viable human embryos – meaning that human embryos who receive gene modification are always destroyed.
The new guidelines from the National Academy of Sciences are significant because they lay a groundwork for future policy on human gene modification. They cautiously welcome the use of gene therapy on human embryos who are not later targeted for destruction after experimentation concludes.
DiCamillo recalled, however, that “they are merely guidelines – they are advice from the National Academy of the Sciences to the government in regards to future policy. This is not itself a new regulation or policy that the government has established.”
The ethics of gene editing has been questioned for several years – the Congregation for the Doctrine of the Faith addressed the issue in Dignitas personae, its 2008 instruction on certain bioethical questions. It has become more pressing recently, however, because a new technique known as CRISPR is easier to use and less expensive than previous means of gene editing.
Although the ethical questions surrounding gene modification are many and there are a number of problematic applications of these technologies, DiCamillo cautioned Catholics not to renounce completely human gene modification: “We don’t want to be hyper-reactive to the dangers. We have to realize there’s a great deal of good that can be done here.”
He pointed again to the kinds of modifications that can treat deadly genetic diseases and treatments that can be done in an ethical manner, with full respect to the dignity of human persons.
“We do need to be attentive to where the dangers are,” he warned, “but we don’t want to … automatically consider any kind of gene editing to be automatically a problem.”
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“The Holy See gave no reason for the decision.”
Is it just me, or does this seem a tad high-handed?
Doesn’t the Holy Father owe the Diocese of Arecibo an explanation? Is Bishop Torres a danger to his flock in any way?
And what are his fellow bishops supposed to read into his removal?
For a papacy that claims to be all about the synodality of synodality, taking such an action in a virtual vacuum appears altogether centralized and authoritarian.
It certainly seems that the Church — as, indeed, the world — is at a hugely consequential inflection point.
No, it’s not just you.
To the new disoriented clericalist elites, the Church is their centrally managed corporation, and they all work as regional managers for “the bouncer-in-charge” Pontiff Francis.
See Phil Lawler in Catholic Culture, Mar. 9.Gi
“I think that for quite some time many bishops have been watching with concern what is happening in the Church and we have resisted believing what is happening. Today more than ever we must remember our calling to be prophets” (Bishop Daniel Fernández Torres).
When faithful priests and bishops are persecuted by the Church we know something is terribly amiss. That a bishop seeking to safeguard his seminarians, affirming conscientious refusal of vaxx by member of his fold is censured and removed, while elsewhere Catholics are permitted license by bishops to receive the Eucharist when living in adultery and same sex relationships.
Are we approaching perhaps that final test of our faith? Men like Bishop Torres whatever transpires forge the path for us.
Blessings of peace and ever increasing wisdom.
Man is known by what he says and how he acts. Thank God for Bishop Daniel Fernández Torres and others of his ilk.
Romans 8:31 What then shall we say to these things? If God is for us, who can be against us?
Psalm 27:10 For my father and my mother have forsaken me, but the Lord will take me in.
1 Peter 5:8 Be sober-minded; be watchful. Your adversary the devil prowls around like a roaring lion, seeking someone to devour.
Philippians 3:13-14 Brothers, I do not consider that I have made it my own. But one thing I do: forgetting what lies behind and straining forward to what lies ahead, I press on toward the goal for the prize of the upward call of God in Christ Jesus.
2 Corinthians 12:9 But he said to me, “My grace is sufficient for you, for my power is made perfect in weakness.” Therefore I will boast all the more gladly of my weaknesses, so that the power of Christ may rest upon me.
Romans 15:13 May the God of hope fill you with all joy and peace in believing, so that by the power of the Holy Spirit you may abound in hope.
Wasn’t Puerto Rico the place that shut down the Mass of the Ages rather precipitously?
“For a papacy that claims to be all about the synodality of synodality, taking such an action in a virtual vacuum appears altogether centralized and authoritarian.”
Curious. Bishops like Bill Morris in Australia were ejected from the episcopacy. Rome has always been about centralization and authoritarianism. The people complaining usually are allies, personal or ideological.
A bishop who refuses to collaborate with fellow bishops on a seminary, who bucks the trend in favor of public health and safety–that seems like more serious reasons than other bishops getting the pink slip.
It depends on whose ox is being gored.
There has to be more to the story than this.
If being a “traditionalist” and not being “collegial” are the reasons Torres was fired, there are quite a few bishops in the United States whose job would be on the line.
I think people who understand Spanish and have access to Puerto Rican media may be able to find out more information.